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β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization

The global COVID-19 pandemic became more threatening especially after the introduction of the second and third waves with the current large expectations for a fourth one as well. This urged scientists to rapidly develop a new effective therapy to combat SARS-CoV-2. Based on the structures of β-adren...

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Detalles Bibliográficos
Autores principales: Hamed, Mohammed I. A., Darwish, Khaled M., Soltane, Raya, Chrouda, Amani, Mostafa, Ahmed, Abo Shama, Noura M., Elhady, Sameh S., Abulkhair, Hamada S., Khodir, Ahmed E., Elmaaty, Ayman Abo, Al-karmalawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043270/
https://www.ncbi.nlm.nih.gov/pubmed/35493159
http://dx.doi.org/10.1039/d1ra04820a