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Generation and application of TGFβ-educated human Vγ9Vδ2 T cells

Clinical trials that tested the antitumor activity of γδ T cells have been mostly unsuccessful. To address this, we expanded human Vγ9Vδ2 T cells in TGFβ1, a cytokine which enhances their viability, trafficking properties, and intrinsic antitumor activity. This protocol summarizes the production and...

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Detalles Bibliográficos
Autores principales: Parente-Pereira, Ana C., Beatson, Richard E., Davies, David M., Hull, Caroline, Whilding, Lynsey M., Porter, Joanna C., Maher, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043756/
https://www.ncbi.nlm.nih.gov/pubmed/35496793
http://dx.doi.org/10.1016/j.xpro.2022.101319