Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes

Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue – BCN acid – whose facile functionalization via amide bond formation yields more stable derivatives than the classically enc...

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Autores principales: Rady, Tony, Mosser, Michel, Nothisen, Marc, Erb, Stephane, Dovgan, Igor, Cianférani, Sarah, Wagner, Alain, Chaubet, Guilhem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043778/
https://www.ncbi.nlm.nih.gov/pubmed/35494363
http://dx.doi.org/10.1039/d1ra07905k
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author Rady, Tony
Mosser, Michel
Nothisen, Marc
Erb, Stephane
Dovgan, Igor
Cianférani, Sarah
Wagner, Alain
Chaubet, Guilhem
author_facet Rady, Tony
Mosser, Michel
Nothisen, Marc
Erb, Stephane
Dovgan, Igor
Cianférani, Sarah
Wagner, Alain
Chaubet, Guilhem
author_sort Rady, Tony
collection PubMed
description Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue – BCN acid – whose facile functionalization via amide bond formation yields more stable derivatives than the classically encountered carbamates.
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spelling pubmed-90437782022-04-28 Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes Rady, Tony Mosser, Michel Nothisen, Marc Erb, Stephane Dovgan, Igor Cianférani, Sarah Wagner, Alain Chaubet, Guilhem RSC Adv Chemistry Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue – BCN acid – whose facile functionalization via amide bond formation yields more stable derivatives than the classically encountered carbamates. The Royal Society of Chemistry 2021-11-17 /pmc/articles/PMC9043778/ /pubmed/35494363 http://dx.doi.org/10.1039/d1ra07905k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Rady, Tony
Mosser, Michel
Nothisen, Marc
Erb, Stephane
Dovgan, Igor
Cianférani, Sarah
Wagner, Alain
Chaubet, Guilhem
Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes
title Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes
title_full Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes
title_fullStr Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes
title_full_unstemmed Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes
title_short Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes
title_sort bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043778/
https://www.ncbi.nlm.nih.gov/pubmed/35494363
http://dx.doi.org/10.1039/d1ra07905k
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