Systematic characterization of metabolic profiles of ingenol in rats by UPLC-Q/TOF-MS and NMR in combination with microbial biotransformation

Ingenol, as the precursor of the marketed drug ingenol mebutate, has been proven to have a variety of bioactivities. The purpose of this study was to identify the metabolites of ingenol using ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-Q/TOF-MS) combined...

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Detalles Bibliográficos
Autores principales: Xiao, Si-Jia, Li, Shan-Shan, Xie, Bin, Chen, Wei, Xu, Xi-Ke, Zu, Xian-Peng, Shen, Yun-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043799/
https://www.ncbi.nlm.nih.gov/pubmed/35498090
http://dx.doi.org/10.1039/d1ra07915h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043799/
https://www.ncbi.nlm.nih.gov/pubmed/35498090
http://dx.doi.org/10.1039/d1ra07915h

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