Effect of DNA modifications on the transition between canonical and non-canonical DNA structures in CpG islands during senescence

Patterns and levels of DNA modifications play important roles in senescence. Two major epigenetic modifications of DNA, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), target CpG sites. Importantly, CpG concentrated regions, known as CpG islands, contain GC-rich sequences, which have the...

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Detalles Bibliográficos
Autores principales: Matsumoto, Saki, Tateishi-Karimata, Hisae, Ohyama, Tatsuya, Sugimoto, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043837/
https://www.ncbi.nlm.nih.gov/pubmed/35496393
http://dx.doi.org/10.1039/d1ra07201c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043837/
https://www.ncbi.nlm.nih.gov/pubmed/35496393
http://dx.doi.org/10.1039/d1ra07201c

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