Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis

Glutamine metabolism, known as glutaminolysis, is abnormally activated in many cancer cells with KRAS or BRAF mutations or active c-MYC. Glutaminolysis plays an important role in the proliferation of cancer cells with oncogenic mutations. In this study, we characterized radiation-induced cell death,...

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Detalles Bibliográficos
Autores principales: Fujimoto, Masaki, Higashiyama, Ritsuko, Yasui, Hironobu, Yamashita, Koya, Inanami, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043980/
https://www.ncbi.nlm.nih.gov/pubmed/35452996
http://dx.doi.org/10.1016/j.tranon.2022.101431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043980/
https://www.ncbi.nlm.nih.gov/pubmed/35452996
http://dx.doi.org/10.1016/j.tranon.2022.101431

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