Scalable synthesis of favipiravir via conventional and continuous flow chemistry

Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthe...

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Detalles Bibliográficos
Autores principales: Tiyasakulchai, Thanat, Charoensetakul, Netnapa, Khamkhenshorngphanuch, Thitiphong, Thongpanchang, Chawanee, Srikun, Onsiri, Yuthavong, Yongyuth, Srimongkolpithak, Nitipol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044180/
https://www.ncbi.nlm.nih.gov/pubmed/35493228
http://dx.doi.org/10.1039/d1ra06963b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044180/
https://www.ncbi.nlm.nih.gov/pubmed/35493228
http://dx.doi.org/10.1039/d1ra06963b

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