Scalable synthesis of favipiravir via conventional and continuous flow chemistry

Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthe...

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Autores principales: Tiyasakulchai, Thanat, Charoensetakul, Netnapa, Khamkhenshorngphanuch, Thitiphong, Thongpanchang, Chawanee, Srikun, Onsiri, Yuthavong, Yongyuth, Srimongkolpithak, Nitipol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044180/
https://www.ncbi.nlm.nih.gov/pubmed/35493228
http://dx.doi.org/10.1039/d1ra06963b
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author Tiyasakulchai, Thanat
Charoensetakul, Netnapa
Khamkhenshorngphanuch, Thitiphong
Thongpanchang, Chawanee
Srikun, Onsiri
Yuthavong, Yongyuth
Srimongkolpithak, Nitipol
author_facet Tiyasakulchai, Thanat
Charoensetakul, Netnapa
Khamkhenshorngphanuch, Thitiphong
Thongpanchang, Chawanee
Srikun, Onsiri
Yuthavong, Yongyuth
Srimongkolpithak, Nitipol
author_sort Tiyasakulchai, Thanat
collection PubMed
description Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production.
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spelling pubmed-90441802022-04-28 Scalable synthesis of favipiravir via conventional and continuous flow chemistry Tiyasakulchai, Thanat Charoensetakul, Netnapa Khamkhenshorngphanuch, Thitiphong Thongpanchang, Chawanee Srikun, Onsiri Yuthavong, Yongyuth Srimongkolpithak, Nitipol RSC Adv Chemistry Decagram scale synthesis of favipiravir was performed in 9 steps using diethyl malonate as cheap starting material. Hydrogenation and bromination steps were achieved by employing a continuous flow reactor. The synthetic process provided a total of 16% yield and it is suitable for larger-scale synthesis and production. The Royal Society of Chemistry 2021-12-01 /pmc/articles/PMC9044180/ /pubmed/35493228 http://dx.doi.org/10.1039/d1ra06963b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tiyasakulchai, Thanat
Charoensetakul, Netnapa
Khamkhenshorngphanuch, Thitiphong
Thongpanchang, Chawanee
Srikun, Onsiri
Yuthavong, Yongyuth
Srimongkolpithak, Nitipol
Scalable synthesis of favipiravir via conventional and continuous flow chemistry
title Scalable synthesis of favipiravir via conventional and continuous flow chemistry
title_full Scalable synthesis of favipiravir via conventional and continuous flow chemistry
title_fullStr Scalable synthesis of favipiravir via conventional and continuous flow chemistry
title_full_unstemmed Scalable synthesis of favipiravir via conventional and continuous flow chemistry
title_short Scalable synthesis of favipiravir via conventional and continuous flow chemistry
title_sort scalable synthesis of favipiravir via conventional and continuous flow chemistry
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044180/
https://www.ncbi.nlm.nih.gov/pubmed/35493228
http://dx.doi.org/10.1039/d1ra06963b
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