Design and synthesis of water-soluble grifolin prodrugs for DNA methyltransferase 1 (DNMT1) down-regulation

DNA methylation and gene silencing play indispensable roles in the epigenetic landscape and gene expression. DNA methyltransferase 1 (DNMT1), a member of the DNMT family, which catalyzes the addition of methyl groups on DNA has been identified to have a close relationship with tumorigenesis. But DNM...

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Detalles Bibliográficos
Autores principales: Wang, Liguo, Wu, Yue, Li, Zhenzhen, Lan, Tianlong, Zhao, Xu, Lv, Wenxing, Shi, Feng, Luo, Xiangjian, Rao, Yu, Cao, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044205/
https://www.ncbi.nlm.nih.gov/pubmed/35493211
http://dx.doi.org/10.1039/d1ra06648j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044205/
https://www.ncbi.nlm.nih.gov/pubmed/35493211
http://dx.doi.org/10.1039/d1ra06648j

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