Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation

The design and synthesis of a new chiral aminophosphinite-ligated ruthenium complex is described. The ruthenium complex, [Ru(AMP)(2)(CH(3)CN)(2)][BPh(4)](2) {AMP = (S)-tert-butyl 1-(diphenylphosphinooxy)-3-methylbutan-2-ylcarbamate}, has been found to catalyze nucleophilic addition of phenol and car...

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Detalles Bibliográficos
Autores principales: Jena, Rajesh K., Das, Dhiraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044493/
https://www.ncbi.nlm.nih.gov/pubmed/35492500
http://dx.doi.org/10.1039/d1ra06824e
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author Jena, Rajesh K.
Das, Dhiraj
author_facet Jena, Rajesh K.
Das, Dhiraj
author_sort Jena, Rajesh K.
collection PubMed
description The design and synthesis of a new chiral aminophosphinite-ligated ruthenium complex is described. The ruthenium complex, [Ru(AMP)(2)(CH(3)CN)(2)][BPh(4)](2) {AMP = (S)-tert-butyl 1-(diphenylphosphinooxy)-3-methylbutan-2-ylcarbamate}, has been found to catalyze nucleophilic addition of phenol and carboxylic acid to allyl chloride in a highly regioselective fashion with enantiomeric excess ranging from 12 to 90.
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spelling pubmed-90444932022-04-28 Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation Jena, Rajesh K. Das, Dhiraj RSC Adv Chemistry The design and synthesis of a new chiral aminophosphinite-ligated ruthenium complex is described. The ruthenium complex, [Ru(AMP)(2)(CH(3)CN)(2)][BPh(4)](2) {AMP = (S)-tert-butyl 1-(diphenylphosphinooxy)-3-methylbutan-2-ylcarbamate}, has been found to catalyze nucleophilic addition of phenol and carboxylic acid to allyl chloride in a highly regioselective fashion with enantiomeric excess ranging from 12 to 90. The Royal Society of Chemistry 2021-12-09 /pmc/articles/PMC9044493/ /pubmed/35492500 http://dx.doi.org/10.1039/d1ra06824e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Jena, Rajesh K.
Das, Dhiraj
Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation
title Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation
title_full Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation
title_fullStr Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation
title_full_unstemmed Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation
title_short Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation
title_sort enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044493/
https://www.ncbi.nlm.nih.gov/pubmed/35492500
http://dx.doi.org/10.1039/d1ra06824e
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AT dasdhiraj enantioandregioselectiveasymmetricallylicsubstitutionusingachiralaminophosphiniterutheniumcomplexanexperimentalandtheoreticalinvestigation

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