Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA(A) receptors

BACKGROUND: Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABA(A)) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that pathogenic GABA(A) subunits promote misfolding and inefficient assembly of the GA...

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Detalles Bibliográficos
Autores principales: Wang, Meng, Cotter, Edmund, Wang, Ya-Juan, Fu, Xu, Whittsette, Angela L., Lynch, Joseph W., Wiseman, R. Luke, Kelly, Jeffery W., Keramidas, Angelo, Mu, Ting-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044816/
https://www.ncbi.nlm.nih.gov/pubmed/35477478
http://dx.doi.org/10.1186/s13578-022-00783-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044816/
https://www.ncbi.nlm.nih.gov/pubmed/35477478
http://dx.doi.org/10.1186/s13578-022-00783-w

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