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Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA(A) receptors

BACKGROUND: Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABA(A)) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that pathogenic GABA(A) subunits promote misfolding and inefficient assembly of the GA...

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Detalles Bibliográficos
Autores principales:	Wang, Meng, Cotter, Edmund, Wang, Ya-Juan, Fu, Xu, Whittsette, Angela L., Lynch, Joseph W., Wiseman, R. Luke, Kelly, Jeffery W., Keramidas, Angelo, Mu, Ting-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044816/ https://www.ncbi.nlm.nih.gov/pubmed/35477478 http://dx.doi.org/10.1186/s13578-022-00783-w

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