New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies

A new series of 3-methylquinoxaline-based derivatives having the same essential pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for their antiproliferative activities against two human cancer cell lines, MCF-7 and HepG-2. Compounds 15b and 17b demonstrated a signifi...

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Detalles Bibliográficos
Autores principales: Alanazi, Mohammed M., Elkady, Hazem, Alsaif, Nawaf A., Obaidullah, Ahmad J., Alkahtani, Hamad M., Alanazi, Manal M., Alharbi, Madhawi A., Eissa, Ibrahim H., Dahab, Mohammed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044819/
https://www.ncbi.nlm.nih.gov/pubmed/35493991
http://dx.doi.org/10.1039/d1ra05925d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044819/
https://www.ncbi.nlm.nih.gov/pubmed/35493991
http://dx.doi.org/10.1039/d1ra05925d

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