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Activation of the Extracytoplasmic Function σ Factor σ(V) in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-σ Factor RsiV

Clostridioides (Clostridium) difficile is one of the leading causes of nosocomial diarrhea. Lysozyme is a common host defense against many pathogenic bacteria. C. difficile exhibits high levels of lysozyme resistance, which is due in part to the extracytoplasmic functioning (ECF) σ factor, σ(V). It...

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Detalles Bibliográficos
Autores principales: Pannullo, Anthony G., Ellermeier, Craig D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9044953/
https://www.ncbi.nlm.nih.gov/pubmed/35317618
http://dx.doi.org/10.1128/msphere.00092-22