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Depletion of Microglia in an Ex Vivo Brain Slice Culture Model of West Nile Virus Infection Leads to Increased Viral Titers and Cell Death

West Nile virus (WNV) is a major cause of viral encephalitis in the United States. WNV infection of the brain leads to neuroinflammation characterized by activation of microglia, the resident phagocytic cells of the central nervous system (CNS). In this study, depletion of CNS microglia using the CS...

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Detalles Bibliográficos
Autores principales: Stonedahl, Sarah, Leser, Jennifer Smith, Clarke, Penny, Tyler, Kenneth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045141/
https://www.ncbi.nlm.nih.gov/pubmed/35412380
http://dx.doi.org/10.1128/spectrum.00685-22