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Host Polyunsaturated Fatty Acids Potentiate Aminoglycoside Killing of Staphylococcus aureus

Aminoglycoside antibiotics rely on the proton motive force to enter the bacterial cell, and facultative anaerobes like Staphylococcus aureus can shift energy generation from respiration to fermentation, becoming tolerant of aminoglycosides. Following this metabolic shift, high concentrations of amin...

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Detalles Bibliográficos
Autores principales: Beavers, William N., Munneke, Matthew J., Stackhouse, Alex R., Freiberg, Jeffrey A., Skaar, Eric P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045252/
https://www.ncbi.nlm.nih.gov/pubmed/35377191
http://dx.doi.org/10.1128/spectrum.02767-21