Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection

Symptoms of Clostridioides difficile infection (CDI) are attributed largely to two toxins, TcdA and TcdB. About 17–23% of C. difficile isolates produce binary toxin, which enhances C. difficile pathogenesis. Previously, we engineered the nontoxigenic C. difficile strain CCUG37785 (designated as CCUG...

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Detalles Bibliográficos
Autores principales: Wang, Shaohui, Heuler, Joshua, Wickramage, Ishani, Sun, Xingmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045287/
https://www.ncbi.nlm.nih.gov/pubmed/35315695
http://dx.doi.org/10.1128/spectrum.01788-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045287/
https://www.ncbi.nlm.nih.gov/pubmed/35315695
http://dx.doi.org/10.1128/spectrum.01788-21

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