The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function

The matricellular protein CCN5 exerts anti-fibrotic activity in hearts partly by inducing reverse trans-differentiation of myofibroblasts (MyoFBs) to fibroblasts (FBs). CCN5 consists of three structural domains: an insulin-like growth factor binding protein (IGFBP), a von Willebrand factor type C (V...

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Detalles Bibliográficos
Autores principales: Song, Min Ho, Jo, Yongjoon, Kim, Young-Kook, Kook, Hyun, Jeong, Dongtak, Park, Woo Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045603/
https://www.ncbi.nlm.nih.gov/pubmed/35476850
http://dx.doi.org/10.1371/journal.pone.0267629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045603/
https://www.ncbi.nlm.nih.gov/pubmed/35476850
http://dx.doi.org/10.1371/journal.pone.0267629

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