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The TSP-1 domain of the matricellular protein CCN5 is essential for its nuclear localization and anti-fibrotic function
The matricellular protein CCN5 exerts anti-fibrotic activity in hearts partly by inducing reverse trans-differentiation of myofibroblasts (MyoFBs) to fibroblasts (FBs). CCN5 consists of three structural domains: an insulin-like growth factor binding protein (IGFBP), a von Willebrand factor type C (V...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045603/ https://www.ncbi.nlm.nih.gov/pubmed/35476850 http://dx.doi.org/10.1371/journal.pone.0267629 |