A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression

MYC regulates multiple gene programs, raising questions about the potential selectivity and downstream transcriptional consequences of MYC inhibitors as cancer therapeutics. Here, we examined the effect of a small-molecule MYC inhibitor, MYCi975, on the MYC/MAX cistromes, epigenome, transcriptome, a...

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Detalles Bibliográficos
Autores principales: Holmes, Austin G., Parker, J. Brandon, Sagar, Vinay, Truica, Mihai I., Soni, Pritin N., Han, Huiying, Schiltz, Gary E., Abdulkadir, Sarki A., Chakravarti, Debabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045724/
https://www.ncbi.nlm.nih.gov/pubmed/35476451
http://dx.doi.org/10.1126/sciadv.abh3635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045724/
https://www.ncbi.nlm.nih.gov/pubmed/35476451
http://dx.doi.org/10.1126/sciadv.abh3635

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