Cell surface–tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy

Immune-activating cytokines such as interleukin-12 (IL-12) hold strong potential for cancer immunotherapy but have been limited by high systemic toxicities. We describe here an approach to safely harness cytokine biology for adoptive cell therapy through uniform and dose-controlled tethering onto th...

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Detalles Bibliográficos
Autores principales: Jones, Douglas S., Nardozzi, Jonathan D., Sackton, Katharine L., Ahmad, Gulzar, Christensen, Esben, Ringgaard, Lars, Chang, De-Kuan, Jaehger, Ditte E., Konakondla, Jacob V., Wiinberg, Martin, Stokes, Katherine L., Pratama, Alvin, Sauer, Karsten, Andresen, Thomas L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045725/
https://www.ncbi.nlm.nih.gov/pubmed/35476449
http://dx.doi.org/10.1126/sciadv.abi8075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045725/
https://www.ncbi.nlm.nih.gov/pubmed/35476449
http://dx.doi.org/10.1126/sciadv.abi8075

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