Cargando…

Cell surface–tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy

Immune-activating cytokines such as interleukin-12 (IL-12) hold strong potential for cancer immunotherapy but have been limited by high systemic toxicities. We describe here an approach to safely harness cytokine biology for adoptive cell therapy through uniform and dose-controlled tethering onto th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jones, Douglas S., Nardozzi, Jonathan D., Sackton, Katharine L., Ahmad, Gulzar, Christensen, Esben, Ringgaard, Lars, Chang, De-Kuan, Jaehger, Ditte E., Konakondla, Jacob V., Wiinberg, Martin, Stokes, Katherine L., Pratama, Alvin, Sauer, Karsten, Andresen, Thomas L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045725/ https://www.ncbi.nlm.nih.gov/pubmed/35476449 http://dx.doi.org/10.1126/sciadv.abi8075

Ejemplares similares

Anti–phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) for adoptive cell immunotherapy
por: Zheng, Chunxiong, et al.
Publicado: (2023)

Whole-heart multiparametric optical imaging reveals sex-dependent heterogeneity in cAMP signaling and repolarization kinetics
por: Caldwell, Jessica L., et al.
Publicado: (2023)

Mapping the in vivo fitness landscape of a tethered ribosome
por: Radford, Felix, et al.
Publicado: (2023)

Leveraging Endogenous Dendritic Cells to Enhance the Therapeutic Efficacy of Adoptive T-Cell Therapy and Checkpoint Blockade
por: Hübbe, Mie Linder, et al.
Publicado: (2020)

Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments
por: Pagès, Diane-Laure, et al.
Publicado: (2022)

The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells
por: Galazzo, Laura, et al.
Publicado: (2022)

Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold
por: Liu, Shun, et al.
Publicado: (2023)

Anti-PD-1 Therapy with Adjuvant Ablative Fractional Laser Improves Anti-Tumor Response in Basal Cell Carcinomas
por: Olesen, Uffe Høgh, et al.
Publicado: (2021)

ATG16L1 adopts a dual–binding site mode to interact with WIPI2b in autophagy
por: Gong, Xinyu, et al.
Publicado: (2023)

An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
por: Hansen, Stine L., et al.
Publicado: (2023)

The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels
por: Coonen, Laura, et al.
Publicado: (2022)

Structure of the ciliogenesis-associated CPLANE complex
por: Langousis, Gerasimos, et al.
Publicado: (2022)

A dominant function of LynB kinase in preventing autoimmunity
por: Brian, Ben F., et al.
Publicado: (2022)

Investigating trends in those who experience menstrual bleeding changes after SARS-CoV-2 vaccination
por: Lee, Katharine M. N., et al.
Publicado: (2022)

Insights into the evolution of enzymatic specificity and catalysis: From Asgard archaea to human adenylate kinases
por: Verma, Apoorv, et al.
Publicado: (2022)

Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis
por: Bülck, Cynthia, et al.
Publicado: (2023)

Immune characterization of a xenogeneic human lung cross-circulation support system
por: Wu, Wei K., et al.
Publicado: (2023)

Large1 gene transfer in older myd mice with severe muscular dystrophy restores muscle function and greatly improves survival
por: Yonekawa, Takahiro, et al.
Publicado: (2022)

Validation of antibodies: Lessons learned from the Common Fund Protein Capture Reagents Program
por: Roy, Ananda L., et al.
Publicado: (2021)

Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma
por: Hastings, Jordan F., et al.
Publicado: (2023)

Semicircular canal size constrains vestibular function in miniaturized frogs
por: Essner, Richard L., et al.
Publicado: (2022)

Cord blood–derived V(δ)2(+) and V(δ)2(−) T cells acquire differential cell state compositions upon in vitro expansion
por: Ng, Jeremy Wee Kiat, et al.
Publicado: (2023)

Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo
por: Cooper, Rory L., et al.
Publicado: (2023)

Next-generation T cell–activating vaccination increases influenza virus mutation prevalence
por: Bull, Maireid B., et al.
Publicado: (2022)

Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA
por: Bonilla, Steve L., et al.
Publicado: (2022)

Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress
por: Howes, Anna C., et al.
Publicado: (2023)

A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient
por: Rexius-Hall, Megan L., et al.
Publicado: (2022)

Beyond autophagy: LC3-associated phagocytosis and endocytosis
por: Peña-Martinez, Carolina, et al.
Publicado: (2022)

Cryo-EM structure of the human Sirtuin 6–nucleosome complex
por: Chio, Un Seng, et al.
Publicado: (2023)

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding
por: Solon, April L., et al.
Publicado: (2021)

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
por: Rennie, Martin L., et al.
Publicado: (2022)

Macrophage activation drives ovarian failure and masculinization in zebrafish
por: Bravo, Paloma, et al.
Publicado: (2023)

Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males
por: Apostolopoulou, Maria, et al.
Publicado: (2021)

UNC-49 is a redox-sensitive GABA(A) receptor that regulates the mitochondrial unfolded protein response cell nonautonomously
por: Pohl, Franziska, et al.
Publicado: (2023)

RNase H genes cause distinct impacts on RNA:DNA hybrid formation and mutagenesis genome wide
por: Schroeder, Jeremy W., et al.
Publicado: (2023)

Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle
por: Ellinghaus, Thomas L., et al.
Publicado: (2021)

Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges
por: Sanz-Garcia, Enrique, et al.
Publicado: (2022)

Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis
por: Murugan, Nirosha J., et al.
Publicado: (2022)

Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary
por: Umehara, Takashi, et al.
Publicado: (2022)

Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors
por: Smith, Cheryl L., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t88c62uu05ae97jdl2u6dlr1ba