Cargando…

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological processes such as immune responses, organ development, cellular communication, proliferation and homeostasis(1–7). An intrinsic manner of activation that involves a tethered agonist in the N-terminal region of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qu, Xiangli, Qiu, Na, Wang, Mu, Zhang, Bingjie, Du, Juan, Zhong, Zhiwei, Xu, Wei, Chu, Xiaojing, Ma, Limin, Yi, Cuiying, Han, Shuo, Shui, Wenqing, Zhao, Qiang, Wu, Beili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046087/ https://www.ncbi.nlm.nih.gov/pubmed/35418679 http://dx.doi.org/10.1038/s41586-022-04580-w

Ejemplares similares

Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling
por: Jones, Daniel T. D., et al.
Publicado: (2023)

The role of kinetic context in apparent biased agonism at GPCRs
por: Klein Herenbrink, Carmen, et al.
Publicado: (2016)

Structural basis of FPR2 in recognition of Aβ(42) and neuroprotection by humanin
por: Zhu, Ya, et al.
Publicado: (2022)

Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism
por: Bridges, James P, et al.
Publicado: (2022)

GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth
por: Bayin, N S, et al.
Publicado: (2016)

ADGRD1 as a Potential Prognostic and Immunological Biomarker in Non-Small-Cell Lung Cancer
por: Lv, Meiwen, et al.
Publicado: (2022)

GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine
por: Park, Taeyeop, et al.
Publicado: (2019)

Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1)
por: Stephan, Gabriele, et al.
Publicado: (2023)

Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes
por: Frenster, Joshua D, et al.
Publicado: (2020)

Adgrf5 contributes to patterning of the endothelial deep layer in retina
por: Niaudet, C., et al.
Publicado: (2019)

Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133)
por: Fischer, Liane, et al.
Publicado: (2016)

Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit
por: Bianchi, Enrica, et al.
Publicado: (2021)

Structural analysis of the dual agonism at GLP-1R and GCGR
por: Li, Yang, et al.
Publicado: (2023)

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function
por: Lee, Ji-Won, et al.
Publicado: (2016)

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding
por: Huang, Bill X., et al.
Publicado: (2020)

Kinetic basis of partial agonism at NMDA receptors
por: Kussius, Cassandra L, et al.
Publicado: (2009)

Structural basis of efficacy-driven ligand selectivity at GPCRs
por: Powers, Alexander S., et al.
Publicado: (2023)

Structural basis for receptor selectivity and inverse agonism in S1P(5) receptors
por: Lyapina, Elizaveta, et al.
Publicado: (2022)

Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling
por: Frenster, Joshua D., et al.
Publicado: (2021)

Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury
por: Kwon, Heung-Sun, et al.
Publicado: (2023)

Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation
por: Banerjee, Sharmistha, et al.
Publicado: (2023)

Molecular basis of signaling specificity between GIRK channels and GPCRs
por: Touhara, Kouki K, et al.
Publicado: (2018)

Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5
por: Zhang, Hui, et al.
Publicado: (2021)

Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)
por: Wu, Mengyao, et al.
Publicado: (2023)

Structural basis for GPR40 allosteric agonism and incretin stimulation
por: Ho, Joseph D., et al.
Publicado: (2018)

Interaction between GPR110 (ADGRF1) and tight junction protein occludin implicated in blood-brain barrier permeability
por: Huang, Bill X., et al.
Publicado: (2023)

Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs
por: Powers, Alexander S., et al.
Publicado: (2023)

The Adhesion G-Protein-Coupled Receptor GPR115/ADGRF4 Regulates Epidermal Differentiation and Associates with Cytoskeletal KRT1
por: Winkler, Romy, et al.
Publicado: (2022)

Structural basis of ligand binding modes at the human formyl peptide receptor 2
por: Chen, Tong, et al.
Publicado: (2020)

Structural basis for ligand recognition of the neuropeptide Y Y(2) receptor
por: Tang, Tingting, et al.
Publicado: (2021)

G Protein-Coupled Receptors (GPCRs) in Alzheimer’s Disease: A Focus on BACE1 Related GPCRs
por: Zhao, Juan, et al.
Publicado: (2016)

Structural insights into signal transduction of the purinergic receptors P2Y(1)R and P2Y(12)R
por: Li, Beibei, et al.
Publicado: (2022)

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)
por: Lu, Shun, et al.
Publicado: (2017)

Activation of the human chemokine receptor CX3CR1 regulated by cholesterol
por: Lu, Minmin, et al.
Publicado: (2022)

Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
por: Duan, Jia, et al.
Publicado: (2022)

Molecular mechanism of agonism and inverse agonism in ghrelin receptor
por: Qin, Jiao, et al.
Publicado: (2022)

Biased agonism
por: Kenakin, Terry
Publicado: (2009)

Agonizing Hedgehog
por: Weitzman, Jonathan B
Publicado: (2002)

Agon : ballet for twelve dancers
por: Stravinsky, Igor, 1882-1971
Publicado: (1957)

Illuminating the life of GPCRs
por: Böhme, Ilka, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_i23g80tnsn0mehdpg7ishb416h