A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition

Protease inhibitors are among the most powerful antiviral drugs. However, for SARS-CoV-2 only a small number of protease inhibitors have been identified thus far and there is still a great need for assays that efficiently report protease activity and inhibition in living cells. Here, we engineer a s...

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Detalles Bibliográficos
Autores principales: Heilmann, Emmanuel, Costacurta, Francesco, Geley, Stephan, Mogadashi, Seyad Arad, Volland, Andre, Rupp, Bernhard, Harris, Reuben Stewart, von Laer, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046202/
https://www.ncbi.nlm.nih.gov/pubmed/35478219
http://dx.doi.org/10.1038/s42003-022-03277-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046202/
https://www.ncbi.nlm.nih.gov/pubmed/35478219
http://dx.doi.org/10.1038/s42003-022-03277-0

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