Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis

BACKGROUND & AIMS: Dysregulation of liver lipid metabolism is associated with the development and progression of nonalcoholic fatty liver disease, a spectrum of liver diseases including nonalcoholic steatohepatitis (NASH). In the liver, insulin controls lipid homeostasis by increasing triglyceri...

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Detalles Bibliográficos
Autores principales: Uehara, Kahealani, Sostre-Colón, Jaimarie, Gavin, Matthew, Santoleri, Dominic, Leonard, Kelly-Ann, Jacobs, René L., Titchenell, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046248/
https://www.ncbi.nlm.nih.gov/pubmed/35240344
http://dx.doi.org/10.1016/j.jcmgh.2022.02.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046248/
https://www.ncbi.nlm.nih.gov/pubmed/35240344
http://dx.doi.org/10.1016/j.jcmgh.2022.02.015

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