A cryptic pocket in Ebola VP35 allosterically controls RNA binding

Protein-protein and protein-nucleic acid interactions are often considered difficult drug targets because the surfaces involved lack obvious druggable pockets. Cryptic pockets could present opportunities for targeting these interactions, but identifying and exploiting these pockets remains challengi...

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Detalles Bibliográficos
Autores principales: Cruz, Matthew A., Frederick, Thomas E., Mallimadugula, Upasana L., Singh, Sukrit, Vithani, Neha, Zimmerman, Maxwell I., Porter, Justin R., Moeder, Katelyn E., Amarasinghe, Gaya K., Bowman, Gregory R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046395/
https://www.ncbi.nlm.nih.gov/pubmed/35477718
http://dx.doi.org/10.1038/s41467-022-29927-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046395/
https://www.ncbi.nlm.nih.gov/pubmed/35477718
http://dx.doi.org/10.1038/s41467-022-29927-9

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