Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation

OBJECTIVE: There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondrial DNA mutations. We used this mouse model to inves...

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Detalles Bibliográficos
Autores principales: Yu, Xuefei, Arden, Catherine, Berlinguer-Palmini, Rolando, Chen, Chun, Bradshaw, Carla, Smith, Anna LM, Whitehall, Julia, White, Michael, Anderson, Scott, Kattner, Nicole, Shaw, James, Turnbull, Doug, Greaves, Laura C, Walker, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046450/
https://www.ncbi.nlm.nih.gov/pubmed/35390502
http://dx.doi.org/10.1016/j.molmet.2022.101489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046450/
https://www.ncbi.nlm.nih.gov/pubmed/35390502
http://dx.doi.org/10.1016/j.molmet.2022.101489

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