Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model

Novel antimicrobials for effective treatment of uncomplicated gonorrhea are essential, and the first-in-class, oral spiropyrimidinetrione DNA gyrase B inhibitor zoliflodacin appears promising. Using our newly developed Hollow Fiber Infection Model (HFIM), the pharmacodynamics of zoliflodacin was exa...

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Detalles Bibliográficos
Autores principales: Jacobsson, Susanne, Golparian, Daniel, Oxelbark, Joakim, Franceschi, Francois, Brown, David, Louie, Arnold, Drusano, George, Unemo, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046595/
https://www.ncbi.nlm.nih.gov/pubmed/35496288
http://dx.doi.org/10.3389/fphar.2022.874176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046595/
https://www.ncbi.nlm.nih.gov/pubmed/35496288
http://dx.doi.org/10.3389/fphar.2022.874176

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