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PAX-D: study protocol for a randomised placebo-controlled trial evaluating the efficacy and mechanism of pramipexole as add-on treatment for people with treatment resistant depression

INTRODUCTION: Clinical depression is usually treated in primary care with psychological therapies and antidepressant medication. However, when patients do not respond to at least two or more antidepressants within a depressive episode, they are considered to have treatment resistant depression (TRD)...

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Detalles Bibliográficos
Autores principales: Au-Yeung, Sheena Kristine, Griffiths, James, Roberts, Sophie, Edwards, Chloe, Yu, Ly-Mee, Bogacz, Rafal, Rendell, Jennifer, Attenburrow, Mary-Jane, Watson, Stuart, Chan, Fiona, Cipriani, Andrea, Cleare, Anthony, Harmer, Catherine J, Kessler, David, Evans, Jonathan, Lewis, Glyn, Singh, Ilina, Simon, Judit, Harrison, Paul J, Cowen, Phil, Shanyinde, Milensu, Geddes, John, Browning, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9046747/
https://www.ncbi.nlm.nih.gov/pubmed/34810175
http://dx.doi.org/10.1136/ebmental-2021-300282