Unraveling how the Gly526Ser mutation arrests prostaglandin formation from arachidonic acid catalyzed by cyclooxygenase-2: a combined molecular dynamics and QM/MM study

Cyclooxygenases (COXs) are the enzymes responsible for the biosynthesis of prostaglandins, eicosanoids that play a major role in many physiological processes. Particularly, prostaglandins are known to trigger inflammation, and COX-2, the enzyme isoform associated with this inflammatory response, cat...

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Detalles Bibliográficos
Autores principales: Suñer-Rubio, Adrián, Cebrián-Prats, Anna, González-Lafont, Àngels, Lluch, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047453/
https://www.ncbi.nlm.nih.gov/pubmed/35494430
http://dx.doi.org/10.1039/c9ra08860a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047453/
https://www.ncbi.nlm.nih.gov/pubmed/35494430
http://dx.doi.org/10.1039/c9ra08860a

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