Diastereoselective synthesis of atropisomeric pyrazolyl pyrrolo[3,4-d]isoxazolidines via pyrazolyl nitrone cycloaddition to facially divergent maleimides: intensive NMR and DFT studies

A pyrazolyl nitrone (2) underwent 1,3-dipolar cycloadditions to afford some N-substituted maleimides (3a–o). An atropisomeric character was introduced into the formed cycloadducts by using maleimides that have a restricted rotation around the C–N bond. Also, facial selectivity of both endo and exo c...

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Detalles Bibliográficos
Autores principales: Said, Awad I., El-Emary, Talaat I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047523/
https://www.ncbi.nlm.nih.gov/pubmed/35494462
http://dx.doi.org/10.1039/c9ra10039c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047523/
https://www.ncbi.nlm.nih.gov/pubmed/35494462
http://dx.doi.org/10.1039/c9ra10039c

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