Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

The SARS-CoV-2 coronavirus, which causes COVID-19, uses a viral surface spike protein for host cell entry and the human cell-surface transmembrane serine protease, TMPRSS2, to process the spike protein. Camostat mesylate, an orally available and clinically used serine protease inhibitor, inhibits TM...

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Detalles Bibliográficos
Autores principales: Kosinsky, Yuri, Peskov, Kirill, Stanski, Donald R., Wetmore, Diana, Vinetz, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047529/
https://www.ncbi.nlm.nih.gov/pubmed/35412356
http://dx.doi.org/10.1128/spectrum.02167-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047529/
https://www.ncbi.nlm.nih.gov/pubmed/35412356
http://dx.doi.org/10.1128/spectrum.02167-21

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