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Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells
Valosin-containing protein (VCP, also known as p97/Cdc48) comprises six identical 97 kDa VCP protomers and functions as a master regulator of cellular homeostasis. VCP dodecamer in an apo nucleotide status was recently reported, providing a new framework for studying VCP’s diverse biological functio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048083/ https://www.ncbi.nlm.nih.gov/pubmed/35496809 http://dx.doi.org/10.1016/j.xpro.2022.101339 |