Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment

AIMS: To characterize neuroinflammatory and gut dysbiosis signatures that accompany exaggerated exercise fatigue and cognitive/mood deficits in a mouse model of Gulf War Illness (GWI). METHODS: Adult male C57Bl/6N mice were exposed for 28 d (5 d/wk) to pyridostigmine bromide (P.O.) at 6.5 mg/kg/d, b...

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Detalles Bibliográficos
Autores principales: Kozlova, Elena V., Carabelli, Bruno, Bishay, Anthony E., Liu, Rui, Denys, Maximillian E., Macbeth, John C., Piamthai, Varadh, Crawford, Meli’sa S., McCole, Declan F., zur Nieden, Nicole I., Hsiao, Ansel, Curras-Collazo, Margarita C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048156/
https://www.ncbi.nlm.nih.gov/pubmed/34801513
http://dx.doi.org/10.1016/j.lfs.2021.120153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048156/
https://www.ncbi.nlm.nih.gov/pubmed/34801513
http://dx.doi.org/10.1016/j.lfs.2021.120153

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