A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide

Tadalafil and repaglinide, categorized as BCS class II drugs, have low oral bioavailabilities due to their poorly aqueous solubilities and dissolutions. The aim of this study was to enhance the dissolution of tadalafil and repaglinide by co-amorphization technology and evaluate the storage and compr...

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Detalles Bibliográficos
Autores principales: Su, Meiling, Xia, Yanming, Shen, Yajing, Heng, Weili, Wei, Yuanfeng, Zhang, Linghe, Gao, Yuan, Zhang, Jianjun, Qian, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048229/
https://www.ncbi.nlm.nih.gov/pubmed/35492562
http://dx.doi.org/10.1039/c9ra07149k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048229/
https://www.ncbi.nlm.nih.gov/pubmed/35492562
http://dx.doi.org/10.1039/c9ra07149k

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