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A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide
Tadalafil and repaglinide, categorized as BCS class II drugs, have low oral bioavailabilities due to their poorly aqueous solubilities and dissolutions. The aim of this study was to enhance the dissolution of tadalafil and repaglinide by co-amorphization technology and evaluate the storage and compr...
Autores principales: | Su, Meiling, Xia, Yanming, Shen, Yajing, Heng, Weili, Wei, Yuanfeng, Zhang, Linghe, Gao, Yuan, Zhang, Jianjun, Qian, Shuai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048229/ https://www.ncbi.nlm.nih.gov/pubmed/35492562 http://dx.doi.org/10.1039/c9ra07149k |
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