DeepREAL: a deep learning powered multi-scale modeling framework for predicting out-of-distribution ligand-induced GPCR activity

MOTIVATION: Drug discovery has witnessed intensive exploration of predictive modeling of drug–target physical interactions over two decades. However, a critical knowledge gap needs to be filled for correlating drug–target interactions with clinical outcomes: predicting genome-wide receptor activitie...

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Detalles Bibliográficos
Autores principales: Cai, Tian, Abbu, Kyra Alyssa, Liu, Yang, Xie, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048666/
https://www.ncbi.nlm.nih.gov/pubmed/35274689
http://dx.doi.org/10.1093/bioinformatics/btac154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048666/
https://www.ncbi.nlm.nih.gov/pubmed/35274689
http://dx.doi.org/10.1093/bioinformatics/btac154

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