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POIBM: batch correction of heterogeneous RNA-seq datasets through latent sample matching

MOTIVATION: RNA sequencing and other high-throughput technologies are essential in understanding complex diseases, such as cancers, but are susceptible to technical factors manifesting as patterns in the measurements. These batch patterns hinder the discovery of biologically relevant patterns. Unbia...

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Detalles Bibliográficos
Autores principales: Holmström, Susanna, Hautaniemi, Sampsa, Häkkinen, Antti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048693/
https://www.ncbi.nlm.nih.gov/pubmed/35199138
http://dx.doi.org/10.1093/bioinformatics/btac124