Synthesis of new oxadiazol-phthalazinone derivatives with anti-proliferative activity; molecular docking, pro-apoptotic, and enzyme inhibition profile

Background and aim: The current study reports the synthesis and biological evaluation of two novel series of 4-(5-mercapto-1,3,4-oxadiazol-2-yl)phthalazin-1(2H)-one derivatives. Methods: The synthetic reactions were carried out under both conventional and ultrasonic irradiation conditions. The anti-...

Descripción completa

Detalles Bibliográficos
Autores principales: Hekal, Mohamed H., El-Naggar, Abeer M., Abu El-Azm, Fatma S. M., El-Sayed, Wael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048702/
https://www.ncbi.nlm.nih.gov/pubmed/35492649
http://dx.doi.org/10.1039/c9ra09016a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048702/
https://www.ncbi.nlm.nih.gov/pubmed/35492649
http://dx.doi.org/10.1039/c9ra09016a

Ejemplares similares