Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al(2)O(3) was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive...

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Autores principales: Yao, Ming, Zhang, Jingjing, Yang, Sen, Xiong, Hangxing, Li, Li, Liu, E., Shi, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048840/
https://www.ncbi.nlm.nih.gov/pubmed/35492642
http://dx.doi.org/10.1039/d0ra00251h
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author Yao, Ming
Zhang, Jingjing
Yang, Sen
Xiong, Hangxing
Li, Li
Liu, E.
Shi, Hong
author_facet Yao, Ming
Zhang, Jingjing
Yang, Sen
Xiong, Hangxing
Li, Li
Liu, E.
Shi, Hong
author_sort Yao, Ming
collection PubMed
description Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al(2)O(3) was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.
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spelling pubmed-90488402022-04-28 Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide Yao, Ming Zhang, Jingjing Yang, Sen Xiong, Hangxing Li, Li Liu, E. Shi, Hong RSC Adv Chemistry Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al(2)O(3) was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst. The Royal Society of Chemistry 2020-01-23 /pmc/articles/PMC9048840/ /pubmed/35492642 http://dx.doi.org/10.1039/d0ra00251h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yao, Ming
Zhang, Jingjing
Yang, Sen
Xiong, Hangxing
Li, Li
Liu, E.
Shi, Hong
Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide
title Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide
title_full Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide
title_fullStr Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide
title_full_unstemmed Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide
title_short Efficient synthesis of 1-iodoalkynes via Al(2)O(3) mediated reaction of terminal alkynes and N-iodosuccinimide
title_sort efficient synthesis of 1-iodoalkynes via al(2)o(3) mediated reaction of terminal alkynes and n-iodosuccinimide
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048840/
https://www.ncbi.nlm.nih.gov/pubmed/35492642
http://dx.doi.org/10.1039/d0ra00251h
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