Homozygotes NAT2*5B slow acetylators are highly associated with hepatotoxicity induced by anti-tuberculosis drugs

BACKGROUND: Distinct N-acetyltransferase 2 (NAT2) slow acetylators genotypes have been associated with a higher risk to develop anti-tuberculosis drug-induced hepatotoxicity (DIH). However, studies have not pointed the relevance of different acetylation phenotypes presented by homozygotes and compou...

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Detalles Bibliográficos
Autores principales: El-Jaick, Kenia Balbi, Ribeiro-Alves, Marcelo, Soares, Marcos Vinícius Guimarães, de Araujo, Gabriela Eduardo França, Pereira, Gabriel Rodrigues Coutinho, Rolla, Valeria Cavalcanti, Mesquita, Joelma Freire De, De Castro, Liane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049236/
https://www.ncbi.nlm.nih.gov/pubmed/35588539
http://dx.doi.org/10.1590/0074-02760210328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049236/
https://www.ncbi.nlm.nih.gov/pubmed/35588539
http://dx.doi.org/10.1590/0074-02760210328

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