Cargando…
Homozygotes NAT2*5B slow acetylators are highly associated with hepatotoxicity induced by anti-tuberculosis drugs
BACKGROUND: Distinct N-acetyltransferase 2 (NAT2) slow acetylators genotypes have been associated with a higher risk to develop anti-tuberculosis drug-induced hepatotoxicity (DIH). However, studies have not pointed the relevance of different acetylation phenotypes presented by homozygotes and compou...
Autores principales: | El-Jaick, Kenia Balbi, Ribeiro-Alves, Marcelo, Soares, Marcos Vinícius Guimarães, de Araujo, Gabriela Eduardo França, Pereira, Gabriel Rodrigues Coutinho, Rolla, Valeria Cavalcanti, Mesquita, Joelma Freire De, De Castro, Liane |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049236/ https://www.ncbi.nlm.nih.gov/pubmed/35588539 http://dx.doi.org/10.1590/0074-02760210328 |
Ejemplares similares
-
Effect of selection for eventing on the MSTN gene in Brazilian sport horses
por: PADILHA, Felipe Gomes Ferreira, et al.
Publicado: (2018) -
The Differential Effect of NAT2 Variant Alleles Permits Refinement in Phenotype Inference and Identifies a Very Slow Acetylation Genotype
por: Ruiz, Jhon D., et al.
Publicado: (2012) -
Protein N-terminal acetylation: NAT 2007–2008 Symposia
por: Arnesen, Thomas
Publicado: (2009) -
Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosis
por: Pereira, Gabriel Rodrigues Coutinho, et al.
Publicado: (2021) -
In Silico Analyses of a Promising Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis Targeting Superoxide Dismutase I Protein
por: Pereira, Gabriel Rodrigues Coutinho, et al.
Publicado: (2023)