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Non-canonical genomic driver mutations of urethane carcinogenesis
The carcinogen urethane induces pulmonary tumors in mice initiated by an incredibly specific Q(61)L/R oncogenic mutation in the proto-oncogene Kras. Previous Whole-Exome Sequencing of urethane-induced tumors revealed a bias towards A➙T/G and G➙A substitutions. Subsequent ultra-sensitive Maximum-Dept...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049545/ https://www.ncbi.nlm.nih.gov/pubmed/35482806 http://dx.doi.org/10.1371/journal.pone.0267147 |