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Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli

In the last two decades, the production of complex polyketides such as erythromycin and its precursor 6‐deoxyerythronolide B (6‐dEB) was demonstrated feasible in Escherichia coli. Although the heterologous production of polyketide skeleton 6‐dEB has reached 210 mg l(−1) in E. coli, the yield of its...

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Detalles Bibliográficos
Autores principales: Liu, Zhifeng, Xu, Jianlin, Liu, Haili, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049603/
https://www.ncbi.nlm.nih.gov/pubmed/35174640
http://dx.doi.org/10.1111/1751-7915.14000