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The relative stability of trpzip1 and its mutants determined by computation and experiment

Six mutants of the tryptophan zipper peptide trpzip1 have been computationally and experimentally characterized. We determine the varying roles in secondary structure stability of specific residues through a mutation assay. Four of the mutations directly effect the Trp–Trp interactions and two of th...

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Detalles Bibliográficos
Autores principales: Bureau, Hailey R., Quirk, Stephen, Hernandez, Rigoberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049704/
https://www.ncbi.nlm.nih.gov/pubmed/35495997
http://dx.doi.org/10.1039/d0ra00920b