Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors

Saccharomonosporine A was recently reported as a natural anti-cancer agent working through inhibition of a Proviral integration site for Moloney murine leukemia virus-1 (PIM-1) kinase. Structural bioisosteres of this natural product were synthesized and tested against PIM kinase enzymes. They showed...

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Detalles Bibliográficos
Autores principales: AboulMagd, Asmaa M., Hassan, Hossam M., Sayed, Ahmed M., Abdelmohsen, Usama Ramadan, Abdel-Rahman, Hamdy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049778/
https://www.ncbi.nlm.nih.gov/pubmed/35493904
http://dx.doi.org/10.1039/c9ra10216g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049778/
https://www.ncbi.nlm.nih.gov/pubmed/35493904
http://dx.doi.org/10.1039/c9ra10216g

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