Enhancement of ibuprofen solubility and skin permeation by conjugation with l-valine alkyl esters

New ibuprofen derivatives were made via conjugation with l-valine alkyl esters (ValOR), where R was changed from an ethyl to a hexyl group. The ionic structure was confirmed using NMR and FTIR. Specific rotation, solubility in commonly used solvents, thermal properties including phase transitions te...

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Detalles Bibliográficos
Autores principales: Janus, Ewa, Ossowicz, Paula, Klebeko, Joanna, Nowak, Anna, Duchnik, Wiktoria, Kucharski, Łukasz, Klimowicz, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049830/
https://www.ncbi.nlm.nih.gov/pubmed/35492154
http://dx.doi.org/10.1039/d0ra00100g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049830/
https://www.ncbi.nlm.nih.gov/pubmed/35492154
http://dx.doi.org/10.1039/d0ra00100g

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