Novel fatty chain-modified GLP-1R G-protein biased agonist exerts prolonged anti-diabetic effects through targeting receptor binding sites

Here, we design and evaluate novel long-lasting GLP-1R G-protein-biased agonists with promising pharmacological virtues. Firstly, six GLP-1R G-protein-biased peptides (named PX01–PX06), screened by using a previous reported high-throughput autocrine-based method, were fused to the N-terminus of GLP-...

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Detalles Bibliográficos
Autores principales: Wang, Maorong, Yao, Ping, Gao, Minpeng, Jin, Jian, Yu, Yerong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049875/
https://www.ncbi.nlm.nih.gov/pubmed/35497855
http://dx.doi.org/10.1039/c9ra10593j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049875/
https://www.ncbi.nlm.nih.gov/pubmed/35497855
http://dx.doi.org/10.1039/c9ra10593j

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