Rational design of stapled peptides targeting phosphorylated GSK3β for regulating osteoclast differentiation

Glycogen synthase kinase-3β (GSK-3β), has been reported to show essential roles in osteoclast differentiation. Modeled after FRATtide, a peptide derived from a GSK-3 binding protein, here we designed and synthesized a series of stapled peptides targeting phosphorylated GSK3β, and evaluated the corre...

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Detalles Bibliográficos
Autores principales: Liu, Tairong, Cong, Wei, Ye, Lei, Xu, Xike, Liao, Xiufei, Xie, Gang, Cheng, Zhaoxi, Hu, Honggang, Li, Xiang, Liao, Hongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049898/
https://www.ncbi.nlm.nih.gov/pubmed/35492160
http://dx.doi.org/10.1039/d0ra00008f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049898/
https://www.ncbi.nlm.nih.gov/pubmed/35492160
http://dx.doi.org/10.1039/d0ra00008f

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