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Rational design of stapled peptides targeting phosphorylated GSK3β for regulating osteoclast differentiation
Glycogen synthase kinase-3β (GSK-3β), has been reported to show essential roles in osteoclast differentiation. Modeled after FRATtide, a peptide derived from a GSK-3 binding protein, here we designed and synthesized a series of stapled peptides targeting phosphorylated GSK3β, and evaluated the corre...
Autores principales: | Liu, Tairong, Cong, Wei, Ye, Lei, Xu, Xike, Liao, Xiufei, Xie, Gang, Cheng, Zhaoxi, Hu, Honggang, Li, Xiang, Liao, Hongli |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9049898/ https://www.ncbi.nlm.nih.gov/pubmed/35492160 http://dx.doi.org/10.1039/d0ra00008f |
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